Currently in his seventh year in the MD/PhD Combined Degree program at the University of Toronto, Jared is completing his doctoral training in the Fehlings Laboratory.
In the Fehlings Laboratory, Jared has pioneered and characterized a novel microsurgical model of cervical spinal cord injury to assess hand function and evaluate potential therapies. The goal of this research program is to deliver a clinically relevant cervical model of spinal injury that can be used for optimizing therapeutics currently being translated to human medicine.
Jared uses cutting edge axonal and synaptic tracing techniques, in concert with genetically labeled cell types, to determine the efficacy of transplantation of adult and pluripotent stem cells into the cervical injured cord in this award-winning project. Following the completion of this doctoral thesis, Jared hopes to maintain productivity in the lab during his medical training to advance these techniques further in the Fehlings Lab.
Jared is active throughout University of Toronto in leadership capacities for mentorship and Clinician Scientist Training, including: CIHR Strategy for Patient-Oriented Research–Training and Career Development (Committee Member), Clinician Investigator Trainee Association of Canada (Past President), MD/PhD Mentorship Symposia (Founder and Chair), and the Undergraduate Medical Student Affairs Liaison Team, Ethics and Professionalism Committee (Member).
Wilcox JT*, Satkunendrarajah K*, Zuccato JA, Nassiri F, Fehlings MG. (2014) Neural stem cell transplantation enhances functional recovery and reduces astrogliosis in bilateral compressive-contusive cervical spinal cord injury. Original Article. Stem Cells Trans Med;3(10);1148-59. *, co-primary authors.
Iwasaki M, Wilcox JT, Nishimura Y, Zweckberger K, Suzuki H, Wang J, Liu Y, Karadimas SK, Fehlings MG (2014). Synergistic effects of self-assembling peptide and neural stem/progenitor cells to promote tissue repair and forelimb functional recovery in cervical spinal cord injury. Original Article. Biomaterials:35(9);2617-29.
Yoon JY, Appleton T, Cecchini MJ, Correa RJ, Ram VD, Wang X, Ng E, Speechley M, Wilcox JT (2014). It begins with the right supervisor: importance of mentorship and clinician-investigator trainee satisfaction levels in Canada. Original Article. Clinical Investigative Medicine:36(6);e269-76.
Wilcox JT, Cadotte D, Fehlings MG (2012). Spinal cord clinical trials and the role for bioengineering. Review. Neuroscience Letters:519(2);93-102.
Wilcox JT, Lai JKY, Semple E, Brisson BA, Gartley C, Armstrong JN, Betts DH (2011). Neural Stem Sells and Synapticaly-competent Neurons Derived from Canine Embryonic Stem Cells by Lineage Selection with EGF and Noggin: Towards Large Animal Transplantation. Original Article. PLoS One:6(5);e19768.
Wilcox JT, Semple E, Gartley C, Brisson B, Perrault S, Tayade C, Becker S, Lanza R, Betts DH (2009). Characterization of canine embryonic stem cells derived from different niche microenvironments. Original Article. Stem Cells Dev 18(8):1167-1178.
Ruff CA*, Wilcox JT*, Fehlings MG (2010). Stem cells and combination treatments to promote plasticity following spinal cord injury. Review. Experimental Neurology:235(1);78-90. *, co-primary authors.
Wilcox JT, Fehlings MG (2011) The acute clip contusion-compression model of cervical spinal cord injury in the rat. Book Chapter. In: Janowski M (ed) Neuromethods, Springer, Humana Press. Accepted, volume in press.