Wenru Yu obtained her M.D. in Jinzhou Medical University in China. After graduation, she worked as a neurologist in Liaoning Province Hospital for 11 years. She achieved the position of associate professor in the neurological department of Liaoning Province Hospital in 1993. Subsequently, she moved to Sweden to begin scientific research of spinal cord injury. She spent 5 years working in the pathological department in Uppsala University,Sweden. Her projects showed systemic hypothermia had neuroprotective effects through the reduction of neuronal death and plasma protein extravasation after severe spinal cord compression trauma.
In 1999, Dr. Michael Fehlings recruited Dr. Yu to work in his laboratory, where she continues to work in spinal cord injury research as a research associate. Wenru’s projects focus on Fas/FasL mediated apoptosis and inflammation in human and animal models after spinal cord injury and cervical spondylotic myelopathy. She has published papers that highlight the potential contribution of Fas-mediated cell death and inflammation to the pathobiology of spinal cord injury and cervical spondylotic myelopathy. Blocking Fas ligand with a Fas function-blocking antibody in a murine model of CSM dramatically improves neurobehavioural function, attenuates Fas-mediated neural apoptosis and reduces the neuropathological consequences of cord compression in cervical spondylotic myelopathy.
She continues to work on a number of studies including:
1. A study entitled “FasL modulates disruption of the blood-spinal cord barrier, glial scarring and inflammation after spinal cord injury: Evidence from human tissue and mouse models.”
2. Research looking at whether and how CX3CR1 mediates neuronal survival and the inflammatory response in humans and in an animal model of cervical spondylotic myelopathy.